Microwave-assisted Clauson-Kaas synthesis of pyrroles

A new and high yielding synthesis of unstable pyrroles via a modified Clauson-Kaas reaction

An investigation of the reaction requirements to effect the Clauson-Kaas pyrrole synthesis led to the formulation of a new procedure that avoids the contact of pyrroles to heat or strongly acidic conditions that cause decomposition of the desired products. The procedure involves mild hydrolysis of 2,5-dimethoxytetrahydrofuran in water to the activated species 2,5-dihydroxytetrahydrofuran that r...

Microwave-assisted polystyrene sulfonate-catalyzed synthesis of novel pyrroles

UNLABELLED BACKGROUND Pyrroles are widely distributed in nature and important biologically active molecules. The reaction of amines with 2,5-dimethoxytetrahydrofuran is a promising pathway for the synthesis of pharmacologically active pyrroles under microwave irradiation. RESULTS Microwave-induced polystyrenesulfonate-catalyzed synthesis of pyrroles from amines and 2,5-diemthoxytetrahydrof...

Microwave-assisted synthesis of molybdenum oxide nanoparticles

This paper focused on a simple approach for synthesis of molybdenum oxide (MoO3) nanoparticles and reports a facile route for synthesis of such nanoparticles, using microwave irradiation as a homogenous and powerful source of heating, using ethylene glycol as the solvent and heating medium. For more investigations, besides microwave heating, the obtained solutions were also treated by conventio...

Microwave Assisted Organic Synthesis

Microwave Assisted Synthesis of N-Benzylenaminones Catalyzed by Chloroacetic acid

Benzylaminoalkenones and benzylaminoalkenoates 3 were synthesized from reaction of benzylamine with corresponding 1,3-diketones and 1,3-ketoesters in the presence of catalytic amount of chloroacetic acid under microwave radiation. This method offers several advantages including high yield of products, recyclable of the catalyst and easy experimental work-up procedure.